Influence of the Rs2236479 Polymorphism Gene COL18A1 on the Development of Pelvic Floor Dysfunction in Women
Volume 2 - Issue 1
Vishnevskii DA1*, Kasyan GR1, Akulenko LV2, Pushkar D Yu1
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- 1Department of Urology of Moscow State Medical and Stomatology University, AI Evdokimov Ministry of Health of the Russian Federation, Moscow, Russia
- 2Department of Medical Genetics of Moscow State Medical and Stomatology University AI Evdokimov Ministry of Health of the Russian Federation, Moscow, Russia
Vishnevskii DA, Department of Urology of Moscow State Medical and Stomatology University, AI Evdokimov Ministry of Health of the Russian Federation, Moscow, Russia
Received:June 20, 2019; Published:July 01, 2019
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Introduction: The phimosis condition is characterized by the inability to retract the foreskin on the glans, making it impossible
to expose them. Surgical treatment, although effective, has been questioned by the risk to which the patient is exposed. Therefore,
we have opted for the use of topical corticosteroids to resolve this pathology.
Goals: To compare the effectiveness of Dexamethasone and Hyaluronidase + Betamethasone Valerate associated with preputial
massage in the treatment of infantile phimosis, the degree of regression of phimosis, the time needed to achieve complete efficacy,
possible adverse reactions, long-term outcome and parental adherence to treatment in children attending a specialized service in
Blumenau, Santa Catarina.
Materials and methods: Controlled clinical trial, quantitative, non-blind, prospective and randomized sample analysis through
the analysis of 523 patients.
Results: After 1 month of treatment, 435 patients presented some degree of regression and 63 children were referred to surgery.
The success rate in this period was 45.8% in boys who were taking Hyaluronidase + Betamethasone Valerate and 49.8% in those
who used Dexamethasone. In the late evaluation, 398 children reached grade 0, and 213 used Hyaluronidase + Betamethasone
Valerate and 185, Dexamethasone; 39 patients were referred to the postectomy. Adherence to treatment was similar in both groups.
The average time for degree 0 to be reached similar in both.
Conclusion: both topical corticosteroids were effective in the resolution of phimosis. However, in the evaluation after the first
month and in the regression, Dexamethasone proved to be more effective. The time to resolution of the condition was similar for
both. The surgical procedure was taken when there was no clinical improvement. No adverse effects were reported in both groups.
Materials and Methods|