Background: We aim to document if any difference exists for renal functions between metastatic and non-metastatic patients.
Methods: The study population included 12 metastatic and 15 non-metastatic patients. Metastatic renal cancer patients using
the TKIs were compared to non- metastatic patients.
Results: Preoperative estimated glomerular filtration rate (e-GFR) was significantly low in metastatic patients than nonmetastatic
patients (p: 0.048). A trend toward increased acute kidney injury during hospital stay in the non-metastatic group was
observed, but this fell just short of statistical significance (p: 0.109). Two groups did not differ significantly in terms of postoperative
e-GFR (p: 0.256). No statistically significant differences were observed in actual e- GFR between two groups (p: 0.638). No statistically
significant differences were found in pre-TKIs and post-TKIs e-GFR values (p: 0.735). Proteinuria was statistically more common
in metastatic patients than non-metastatic patients (p<0.001). No statistically significant difference in age, sex, follow-up period,
NSAIDs use, antihypertensive and ARBs/ACEIs use were documented between the two groups.
Conclusion: Increased risk for proteinuria was documented in metastatic patients with TKIs use. However, use of the TKIs had
no effect on e- GFR. No statistically significant differences were observed in actual e- GFR between two groups.