Effect of Tyrosine Kinase Inhibitors on Renal Functions
Volume 1 - Issue 2
Özgür Can1, Gülizar Manga Şahin2, Umut Kasapoğlu3, Süleyman Baş4 and Bala Başak Öven Ustaalioğlu5
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- 1Department of Nephrology, Tatvan State Hospital, Turkey
- 2Department of Nephrology, University of Health Sciences, Sultan Abdülhamid Han Training and Research Hospital, Turkey
- 3Department of Nephrology, Ağrı State Hospital, Turkey
- 4Department of Internal Medicine, Haydarpaşa Numune Training and Research Hospital, Turkey
- 5Department of Oncology, Haydarpaşa Numune Training and Research Hospital, Turkey
*Corresponding author:
Özgür Can, Bitlis Tatvan Devlet Hastanesi. Bitlis Tatvan Karayolu Üç Yol Mevkii Tatvan, Bitlis/TÜRKİYE Postal Code:
06434
Received: June 26, 2018; Published: July 02, 2018
DOI: 10.32474/JUNS.2018.01.000106
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Abstract
Background: We aim to document if any difference exists for renal functions between metastatic and non-metastatic patients.
Methods: The study population included 12 metastatic and 15 non-metastatic patients. Metastatic renal cancer patients using
the TKIs were compared to non- metastatic patients.
Results: Preoperative estimated glomerular filtration rate (e-GFR) was significantly low in metastatic patients than nonmetastatic
patients (p: 0.048). A trend toward increased acute kidney injury during hospital stay in the non-metastatic group was
observed, but this fell just short of statistical significance (p: 0.109). Two groups did not differ significantly in terms of postoperative
e-GFR (p: 0.256). No statistically significant differences were observed in actual e- GFR between two groups (p: 0.638). No statistically
significant differences were found in pre-TKIs and post-TKIs e-GFR values (p: 0.735). Proteinuria was statistically more common
in metastatic patients than non-metastatic patients (p<0.001). No statistically significant difference in age, sex, follow-up period,
NSAIDs use, antihypertensive and ARBs/ACEIs use were documented between the two groups.
Conclusion: Increased risk for proteinuria was documented in metastatic patients with TKIs use. However, use of the TKIs had
no effect on e- GFR. No statistically significant differences were observed in actual e- GFR between two groups.
Keywords: Hypertension; Glomerular Filtration Rate; Proteinuria; Tyrosine- Kinase Inhibitors
Abbrevations: RCC: Renal cell carcinoma ; TKIs: Tyrosine-Kinase Inhibitors; AKI: Acute Kidney Injury; NSAIDs: Non-Steroidal
Anti-Inflammatory Drugs; ARBs: Angiotensin Receptor Blockers; ACEIs: Angiotensin Converting Enzyme Inhibitors; ARBs:
Angiotensin Receptor Blockers; CCBs: Calcium Channel Blockers; e- GFR: Estimated Glomerular Filtration Rate
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