Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and
antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus. Important
free radicals are described and biological sources of origin discussed, together with the major antioxidant defense mechanisms.
Examples of the possible consequences of free radical damage are provided with special emphasis on lipid peroxidation. Ginger
(Zingiber officinale), a member of the Zingiberaceae family, is a popular spice used globally especially in most of the Asian countries.
Chemical analysis of ginger shows that it contains over 400 different compounds. The major constituents in ginger rhizomes are
carbohydrates (50-70%), lipids (3-8%), terpenes, and phenolic compounds. Terpene components of ginger include zingiberene,
β-bisabolene, α-farnesene, β-sesquiphellandrene, and α-curcumene, while phenolic compounds include gingerol, paradols, and
shogaol. These gingerols (23-25%) and shogaol (18-25%) are found in higher quantity than others. Besides these, amino acids,
raw fiber, ash, protein, phytosterols, vitamins (e.g., nicotinic acid and vitamin A), and minerals are also present. We selected its
hypolipidemic and weight lost effects in primary and secondary hyperlipidemic patients. Type of Research study: It was placebocontrolled
study. Area of research: Research was conducted in Jinnah hospital, Lahore, Pakistan. Duration of study: It was three
months, from January 2018 to June 2018. Material, Method and Results: Already well understood, clearly explained written consent
was taken from sixty hyperlipidemic patients age range from 18 to 70 years. Both gender male and female patients were enrolled.
Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided
doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same
color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their
base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly. When
duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values.
Three months treatment with 5 grams of Ginger decreased LDL-cholesterol 17.41%, total-cholesterol 8.83% and body weight
2.11%. When compared with placebo group, all changes in mentioned parameters were significant biostatistically. Conclusion: It
was concluded from results of study that active ingredients of ginger lower plasma lipids and body weight significantly, eventually
preventing development of coronary artery disease in primary and secondary hyperlipidemic patients.