Reversal of Rocuronium-Induced Neuromuscular Block with Neostigmine in the Libyan Patients

Volume 1 - Issue 1

Nahd Mohamed Elmaki¹, Mohamad Anwar Hamza², Abtism Ashour Abdlsalam², Belal S. Shbair², Tomader Mohamed Ali³, Abdurrauf Mohammed Gusbi⁴, Anton Hermann⁵ and Abdul M Gbaj⁶*

Received: September 04, 2018;   Published: September 18, 2018

DOI: 10.32474/LOJPCR.2018.01.000103

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Abstract

Background: Reversal of the enduring effect of rocuronium by neostigmine is a common procedure performed in the Libyan hospitals. The reversal of the continuing effect of rocuronium by neostigmine was also evaluated.

Methods: eighty adult surgical patients were included in the study using neostigmine 2.5mg (0.05-0.07mg/kg) to reversal the block induced by rocuronium 0.6 mg/kg. Anaesthesia was induced and maintained using i.v. propofol (2.5mg/kg) and fentanyl (1.5μg/kg). Reversal neuromuscular function was monitored using clinical signs includes patient responsiveness, subjective measurements of muscle strength (5 second head lift, hand grasp), eye opening, and tongue extrusion.

Results: Reversal of block was sustained in all patients from the enduring effect of rocuronium by neostigmine. Ninety-six patients were had a similar time of recovery but eleventh were not. There were no serious adverse effects from neostigmine and no significant changes in any measure of safety.

Conclusions: neostigmine is capable of reversing rocuronium-induced blockade in the Libyan patients by monitoring the muscle strength, eye opening, and tongue extrusion.

Keywords: Acetylcholinesterase; Neostigmine; Propofol; Fentanyl; Anaesthesia; Rocuronium

Abstract| Introduction| Materials and Methods| Results and Discussion| Conclusion| References|