Fasciola hepatica is a trematode parasite with life cycle complex and as an intermediary it uses different species of snails, the
most important is Lymnea truncatula. The definitive hosts being mainly ruminant mammals such as cows, sheep and even humans.
The disease they produce is called fasciolosis and is more likely to find in warm to temperate climates with high humidity. It is an
important parasitic problem in domestic animals and even in humans. This parasite lives in the bile ducts of several mammals. In
order to survive in that environment, the parasite must survive to reactive oxygen species (ROS) of the host and those of its own
metabolism. Here we review 3 antioxidant proteins of the parasite secretory excretory system and explain its possible mechanism
of action. These proteins are: Thioredoxin peroxidase (TPx), Thioredoxin (TRX) and Thioredoxin glutathione reductase, considered
a “general disulfide reductase”. The antioxidant detoxification system of the parasite is thus fully described.
Keywords: Fasciola hepatica; Antioxidant proteins; Secretory excretory system