Application of Nanotechnology for Phyto Constituents: Review Volume 1 - Issue 1

Snehal Bhavsar*

• North Maharashtra University, India

Received: April 26, 2018;   Published: May 16, 2018

*Corresponding author: Snehal Bhavsar, North Maharshtra University, India

DOI: 10.32474/ANOAJ.2018.01.000103

Abstract PDF

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Keywords: Flavonoids, Tannins, Terpenoids, Hydrophilic, Nano Liposomes, Nano Emulsions, Lipid Nanocarries, Phytosomes, Micelles, Herbal Medicines

Introduction

Herbal medicines have been widely used around the world since ancient times. Medicinal plants are most effective when their active constituent reach at the site of action. Most of plant contains flavonoids, tannins, and terpenoids, which are hydrophilic and unable to cross the lipid membranes of the cells so poor absorption, results in less bio availability and efficacy hence need to take in high dose and frequency of dose also increases. If they are formulated using nanotechnology, due to nano ¬structured systems might be able to potentiate the action of plant extracts also reduce the required dose and side effects, and improving activity. Research has shown that use of nanotechnology and formulations like nano liposomes, nano emulsions, lipid nanocarries, phytosomes, micelles and poly (lactic-co-glycolic acid) (PLGA) nanoparticles beneficial in case of phyto constituent they increases the rate of absorption bio availability and result in better effect of herbal medicines [1-10].

The Techniques Commonly Used for the Formulation are:

a) High-pressure homogenization methods

b) Complex coacervation method

c) Co-precipitation method

d) Salting-out method

e) Nano precipitation method or solvent displacement method

f) Solvent emulsification-diffusion method

Types of Nano Pharmaceuticals

a) Polymeric nanoparticles

b) Solid lipid nanoparticles

c) Magnetic nanoparticles

d) Metal and inorganic nanoparticles

e) Quantum dots

f) Polymeric micelles

g) Phospholipids micelles

h) Colloidal nano-liposomes

i) Dendrimers

Conclusion

Nanotechnology has potential future for enhancing the activity and overcoming problems associated with herbal medicines and phyto constituents Table 1. By applying nanotechnology principles it is possible to reduce the amount of drug to be loaded and hence prevent many dose-related adverse reactions. Several excellent phyto constituents have been successfully delivered using nanotechnology currently, not many products are available for clinical use, but looking at the amount of research activity happening in this field, the next few years many products being launched in the market for clinical use.

References

1. Mukerjee A, Vishwanathan JK (2009) Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29(10): 3867-3875.
2. Hou J, Zhou SW (2008) Formulation and preparation of glycyrrhizin acid solid lipid nanoparticles. ACTA 30: 1043-1045.
3. Yen FL, Wu TH, Tzeng CW, Lin LT, Lin CC (2010) Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively Yen FL, Wu TH, Tzeng CW, Lin LT, Lin CC (2010) Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively
4. Li D, Zhong X, Zeng Z, Jiang J, Li L, et al. (2009) Application of targeted drug delivery system in Chinese medicine. J Control Rel 138(2): 103-112.
5. Chen Y, Lin X, Park H, Greever R (2009) Study of artemisinin Nanocapsules as anticancer drug delivery systems Nanomedicine: 5(3): 316-322.
6. Tzu-Hui W, Feng-Lin Y, Liang-Tzung L, Tong-Rong T, Chun-Ching L, et al. (2008) Int J Pharm 346(1-2): 160-168.
7. Mukerjee A, Vishwanatha JK (2009) Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29(10): 3867-3875.
8. Min KH, Park K, Kim YS, Bae SM, Lee S, et al. (2008) Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release 127(3): 208-218.
9. Fukuda K, Hibiya Y, Mutoh M (1999) Inhibition of activation protein 1 activity by Berberine in human hepatoma cells. Planta Med 65(4): 381- 383.
10. Zheng Y, Hasworth IS, Zuo Z, Chow MS, Chow AH (2005) Physicochemical and structural characterization of quercetin- beta-cyclodextrin complexes. Journal of Pharmaceutical Sciences. 94(5): 1079-1089.