Synthesis of Some Piperidine, Pyrmidine and Diazipine Compounds Containing Furyl Derivatives

Volume 1 - Issue 5

MS Al-Ajely1* and I M Shaban₂

Received: April 02, 2019;   Published: April 17, 2019

DOI: 10.32474/ANOAJ.2018.01.000124

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Abstract

It was known that nearly 65% of anti-cancer drugs granted market approved by FDA between 210-1015 are heterocyclic compounds and about 95% of heterocyclic compounds are drugs. Heterocyclic compounds containing nitrogen atoms in their structures (nitrogen based)were also proved by FDA during the above period that they form two third of cancer drugs. There are many corresponding reviews associated with the impact and usage of different heterocyclic compounds as anti- platelet, antihypertensions and a lot of biological and medicinal applications. So according to the importance of heterocyclic compounds in therapeutic and a variety of pharmaceutical, medicinal applications which attracts attentions of many researchers on synthesizing new compounds of this class. We are here synthesizing some new nitrogen containing heterocyclic compounds, Piperidine compounds(E_4-8), 1,4-Dihydropyridine derivatives(E_9-20) And finally diazepine compounds(E_31-37)The synthesized compounds were studied using IR and1H NMR Spectral methods and were discussed.

Keywords: Piperidine; Pyrmidine; Azipine; Furfural

Abstract| Introduction| Experimental| Results and Discussion| Conclusion| Acknowledgments| References|