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ISSN: 2637-6660

Archives of Nanomedicine: Open Access Journal

Research Article(ISSN: 2637-6660)

Nicardipine: Concise Review on Analytical Techniques

Volume 1 - Issue 5

Pritam Jain S*, Vrushali Patil A, Ansari Shoaib Ahmed Ayaz Ahmed, Champalal Pawara T and Sanjay Surana J

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    • R.C. Patel Institute of Pharmaceutical Education and Research, India

    *Corresponding author: Pritam Jain S, R.C. Patel Institute of Pharmaceutical Education and Research, India

Received: January 28, 2019;   Published: February 14, 2019

DOI: 10.32474/ANOAJ.2018.01.000123

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Abstract

Nicardipine (NCD) is the dihydropyridine class of calcium channel blockers. This study exits a concise review of analytical methods for the quantification of NCD in pharmaceutical preparations and biological fluids. NCD accessible single or in combination with added drugs in pharmaceutical matrices with many drugs like nifedipine, isradipine, veramipril, amlodipine and Aliskiren. They include numerous analytical techniques defined in this study for NCD were high-performance liquid chromatography (HPLC), UV-spectrophotometry, spectrofluorometry, electrochemical methods and liquid chromatography-mass spectroscopy (LCMS). The concise review explains the percentage utilization of the various approaches for analysis of NCD.

Keywords: Nicardipine; Review; Analytical method; Chromatography

Abbreviations:NCD: Nicardipine; NCD HCl: Nicardipine hydrochloride; AML: Amlodipine; NIF: Nifedipine; ISRA: Isradipine; VRP HCl: Verapamil hydrochloride; DTZ HCl: Diltiazem hydrochloride; FLN: Flunarizine; ALI: Aliskiren; MP: Metoprolol; TRB: Terbutaline; PRO: Propranolol; OXA- Oxazepam; FLUX: Fluoxetine; PIND: Pindolol; SDS: Sodium dodecyl sulphate; TEA: Triethylamine; LCMS: Liquid chromatography- mass spectroscopy; LC/MS/MS: Liquid chromatography- mass spectroscopy- mass spectroscopy; LC-ESI- MS: Liquid chromatography-electrospray- mass spectrometry; RSD: Relative standard deviations; ACC: Accuracy; PRECI: Precision; SS: System suitability; RF: Retention factor; RT: Retention time; TP: Theoretical plate; TF: Tailing factor; RES: Resolution; FR: Flow rate; nm: Nanometre; PDA: Photodiode array detector; SDM: Second derivative method; CAN: Acetonitrile; FA: Formic acid; GCE: Glassy carbon electrode; MPE: Mercury pool electrode; PE: Platinum electrode; CPE: Carbon paste electrode; PMDE: Paste mercury drop electrode; HMDE: Hanging mercury drop electrode

Abstract| Introduction| Chemistry of NCD| Analytical Method| Bioanalytical Method| Analytical Acounts on Nicardipine| Analytical Determination of NCD| Bioanalytical determination of NCD| Spectrophotometry Method| Spectrofluorometric Methods| Liquid Chromatography-Mass Spectrometric Methods| Conclusion| Acknowledgments| References|

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