Anti Ulcer Activity of Leea Indica in
Wistar Albino Rats
Volume 1 - Issue 1
Damayanthi Dalu*
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- Department Of Pharmacology, KL university, India
*Corresponding author:
Damayanthi Dalu, KL college of pharmacy, KL deemed to be university, Guntur,
India
Received: April 30, 2018; Published: May 21, 2018
DOI: 10.32474/ANOAJ.2018.01.000105
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Abstract
Objective: Leea indica is a well known plant with numerous pharmacological activities owing to the presence of the active
constituents. Inspite of numerous therapeutic uses, efficacy of the plant in treating ulcers is not yet evaluated scientifically. Hence an
attempt has been made to evaluate the Antiulcer activity of Leea indica.
Methods: The effect of Leea indica methanolic extract (LIME) on gastric ulcer in pylorus ligation-induced and aspirin induced
models was studied by employing LIME at 200 mg/kg, 400 mg/kg. In both the models Ranitidine (40mg/kg) was employed as the
standard. Depending on the model, parameters evaluated were total acidity, free acidity, volume and pH of gastric fluid, ulcer score
and percent inhibition of ulcer index.
Results: Data were analyzed following graph pad instat version 3.0 followed by Dunnets multiple comparision test. LIME (400mg/
kg) significantly (P<0.01) reduced gastric ulcer index in pylorus ligation-induced and Aspirin induced ulcer models comparable to
that of Standard drug. Histopathological studies confirmed that LIME (400mg/kg) possess anti ulcer activity in both models. The
elicited activity might be owing to the existence of secondary metabolites such as flavonoids, tannins, and saponins.
Conclusion: Obtained results elucidate the Antiulcer activity of Leea indica methanolic extract. Further investigations on
isolation of specific phyto chemicals and elucidating mechanisms of action are needed.
Keywords:Antiulcer, Pylorus Ligation Model, Aspirin Induced Model, Histopathology, Leea Indica; Peptic Ulceration; Vitaceae;
Anti Hyper Lipidaemic; Antitumor; Hydrocarbons
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