*Corresponding author:Felix Nunura, Heart Institute of the Caribbean, Kingston, Jamaica
Received: September 14, 2018; Published: September 23, 2018
To view the Full Article Peer-reviewed Article PDF
Background: Viruses have been implicated in the aetiology/pathogensis of unexplained dilated cardiomyopathy. 6% of adult Jamaicans are HTLV-1 seropositive. We therefore explored the relationship between HTLV-1 infectious cases and unexplained dilated cardiomyopathy in Jamaica.
Methods: Thirteen patients were recruited from Kingston Public Hospital Cardiology clinic, to study HTLV-1 seroprevalence in patients with unexplained dilated cardiomyopathy (WHO criteria: LVEF< 45 %, LVIDd>117% of upper limit for age and BSA without evidence of coronary disease, severe hypertension, excess alcohol intake, valvular heart disease and HIV infection). The HTLV-1 seroprevalence in a group of patients without dilated cardiomyopathy registered in the cardiology clinic was then compared. HTLV- 1 antibodies were detected by ELISA and confirmed where positive by Western Blot. Logistic regression was used to assess the association between HTLV-1 seropositivity and unexplained dilated cardiomyopathy.
Results: HTLV1 seroprevalence in 11 patients (7 males, 3 females) with unexplained dilated cardiomyopathy and 30 (11 males, 19 females) controls were compared. Three (27%) patients with cardiomyopathy and 3 (10%) of controls had HTLV-1 antibodies the crude OR (95%CI) for HTLV1 seropositivity was 3.36 (0.57-20.10). The age and sex adjusted OR (95%CI) was 2.71(0.43-17.19).
Conclusion: There may be an association between HTLV-1 infection and unexplained dilated cardiomyopathy in Jamaica. A larger study is required to further explore this potential relationship.
Bio chemistryUniversity of Texas Medical Branch, USA
Department of Criminal JusticeLiberty University, USA
Department of PsychiatryUniversity of Kentucky, USA
Department of MedicineGally International Biomedical Research & Consulting LLC, USA
Department of Urbanisation and AgriculturalMontreal university, USA
Oral & Maxillofacial PathologyNew York University, USA
Gastroenterology and HepatologyUniversity of Alabama, UK
Department of MedicineUniversities of Bradford, UK
OncologyCirculogene Theranostics, England
Radiation ChemistryNational University of Mexico, USA
Analytical ChemistryWentworth Institute of Technology, USA
Minimally Invasive SurgeryMercer University school of Medicine, USA
Pediatric DentistryUniversity of Athens , Greece
The annual scholar awards from Lupine Publishers honor a selected number Read More...
We know the financial complexity of Individual read more...
The annual scholar awards from Lupine Publishers honor a selected number read more...