Cardiac Remodeling During the Morphogenesis of Neuroleptic Cardiomyopathy

Volkov VP*

Received: August 30, 2018;   Published: September 07, 2018

DOI: 10.32474/ACR.2018.01.000115

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Abstract

Introduction: A neuroleptic cardiomyopathy NCMP belongs to secondary specific metabolic dilated cardiomyopathies. It is caused by side cardiotoxic effect of antipsychotic preparations. In its development NCMP passes three clinical stages: 1) latent, 2) developed and 3) terminal.

Aim: A morphometric study of the macroscopic heart condition in each clinical stage of NCMP.

Material and methods: The autopsy protocols of 80 dead persons with NCMP in various stages and of 100 persons who did not have any accompanying cardiac pathology were studied. For analysis of the received data the original author’s method that we had developed for such studies was used.

Results: All macroscopic cardiac parameters in the case of NCMP statistically significantly differ from normal one, but no significant differences in various clinical stages of NCMP.

Conclusion: The process of cardiac remodeling on the organ level ends during the latent stage of the disease. Progression of myocardial dysfunction is connected with changes of myocardium microstructure.

Keywords: Neuroleptic cardiomyopathy; morphogenesis; remodeling of a heart; morphometric research

Abstract| Introduction| Material and Methods| Results| Discussion| Conclusion| References|