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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Research Article(ISSN: 2637-6628)

Overexpression of Neuregulin-1 Type III has Impact on Visual Function in Mice Volume 5 - Issue 3

Nan Su1,3, Weiqi Zhang2, Nicole Eter1, Peter Heiduschka1* and Mingyue Zhang2*

  • 1Department of Ophthalmology, Research laboratory, University Hospital Muenster, Germany
  • 2Lab for Molecular Neuroscience, Clinic for mental Health, University Hospital Muenster, Germany
  • 3Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, People’s Republic of China, China

Received:March 10, 2021   Published:March 17, 2021

Corresponding author: Mingyue Zhang, Lab for molecular neuroscience, Clinic for Mental Health, University Hospital Muenster, Muenster, Germany

DOI: 10.32474/OJNBD.2021.05.000215

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Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an Epidermal Growth Factor (EGF) like domain. It is thought to play a role in neural development and has been linked to neuropsychiatric disorder. Abnormal Nrg1 expression has been observed in schizophrenia. Moreover, there is more and more evidence found about pathological changes of the retina regarding structural, neurochemical and physiological parameters. However, mechanisms of these changes are not well known. To investigate this, we analyzed function of the visual system using Electroretinography (ERG) and measurement of Visual Evoked Potentials (VEP) in a transgenic mouse overexpressing Nrg1 type III. ERG amplitudes tended to be higher in transgenic mice in younger animals, whereas the amplitudes were almost similar in older mice. VEP amplitudes are larger in transgenic mice in both younger and older animals, with significance in older animals. Nonetheless, latencies did not differ considerably in both age groups (wt & tg). Our data show for the first time that overexpression of Nrg1 type III changed visual function in transgenic mice. Overall, this Investigation of visual function in transgenic mice is helpful for understanding corresponding changes that occur in schizophrenia, as they may find use as biomarkers for psychiatric disorders as well as a potential.

Abstract| Introduction| Materials and Methods| Results| Discussion| Acknowledgments| References|

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