Successful Endoscopic Treatment of Refractory Postoperative Duodenocutaneous Fistula using Fibrin Sealant Volume 1 - Issue 2

Adam Dmitruk¹, Anna Pietrzak*^1,2, Maciej Rupinski^,2, Lukasz Zyskowski¹ and Tomasz Olesinski¹

• ¹ Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland
• ²Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, Warsaw, Poland

Received: July 02, 2018;   Published: July 09, 2018

*Corresponding author: Anna Pietrzak, Roentgen 5 Str, 02-781 Warsaw, Poland

DOI: 10.32474/CTGH.2018.01.000109

 

Abstract PDF

---

Case Report

Iatrogenic, postoperative enteroatmospheric fistulas remain difficult to manage but common problem after gastrointestinal surgery. Surgical revision, after failure of conservative treatment is not only partially efficient but also carries a high mortality risk, mainly due to patients’ general condition and usually multiples comorbidities. Because of that alternative minimally invasive techniques are extensively studied, but unfortunately the data are still confounding [1,2]. We present a case of 38 – y.o. man with past history of nephrolithiasis, accidentally diagnosed with 30 mm gastrointestinal stromal tumour of the duodenum (Figures 1a-1c).

Tumour resection with end-to-end anastomosis of transversal duodenum was performed, but the procedure was complicated by massive intraabdominal bleeding leading to acute pancreatitis and finally to enterocutaneous fistula forming. In course of treatment, the patient required five reoperations with Roux-en-Y resection and sewing patch on the fistula’s enteral orifice, but no one was efficient (Figures 2a& 2b). To avoid another reoperation we decided to perform endoscopic fistula closure by injection fibrin glue (Tisseel, Baxter) into the internal opening (Figures 3a-3c). Procedure was performed via catheter using standard Olympus videoendoscope. We observed immediate fistula closing, and there were no early nor late complications related to the procedure. Patient was discharged after 67 days of hospital stay. After 11 months of follow-up patient remains cured (Figure 4). In conclusion, the fibrin sealant treatment is safer and much less invasive viable option, and it should be taken into account in selected cases [3].It appears that fistula closure is more efficient if performed from the internal opening.

References

1. Galie K, Whitlow Cg (2006) Postoperative enterocutaneous fistula: when to reoperate and how to succeed. Clin Colon Rectal Surg 19(4): 237-246.
2. Kumar N, Larsen MC, Thompson CC (2014) Endoscopic management of gastrointestinal fistulae. Gastrenterol Hepatol 10(8): 495-452.
3. Lippert E, Klebl FH, Schweller F (2011) Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract. Int J Colorectal Dis 26(3): 303-311.