MDCT in Diagnosis of Anomalies of Coronary Artery Origin and Course a Coronary MDCT-Angiographic study of 9572 patients

Coronary artery anomalies are a diverse group of congenital heart diseases with manifestations and pathological mechanisms are highly variable. Coronary anomalies include anomalies of origin and course, anomalies of intrinsic coronary arterial anatomy like myocardial bridge, anatomy of coronary termination as coronary artery fistula and anomalous anastomotic vessels. Anomalies of coronary origin and course may associated with arrhythmias, myocardial infarction and sudden cardiac deaths in young people, especially on effort like athletes. We study 9572 patients with coronary MDCT-angiography to evaluate the type and the incidence of coronary anomalies of origin and course[1,2].


Background
Coronary artery anomalies are a diverse group of congenital heart diseases with manifestations and pathological mechanisms are highly variable. Coronary anomalies include anomalies of origin and course, anomalies of intrinsic coronary arterial anatomy like myocardial bridge, anatomy of coronary termination as coronary artery fistula and anomalous anastomotic vessels. Anomalies of coronary origin and course may associate with arrhythmias, myocardial infarction and sudden cardiac deaths in young people, especially on effort like athletes. We study 9572 patients with coronary MDCT-angiography to evaluate the type and the incidence of coronary anomalies of origin and course.

Methods
All patients who underwent coronary CT-angiography by MDCT 64O Aquilion Toshiba equipment (IV contrast medium, gantry rotation of 0.33 msec, slice thickness 0.5mm) in MEDIC HCMC Viet Nam, from January 2016 to January 2019 were included. The main indications of CT-angiography were acute coronary syndrome, stable angina, coronary CT-angiography prior to surgery, congenital heart diseases involving coronary artery [1,2] The CT-angiograms with coronary anomalies were selected and analysed. The anomalies of coronary origin and course were assessed [3,4].

Results
We included 9572 pts with anomalies of coronary origin and course based on results of CT-angiograms that were interpreted by two cardiologists. Anomalous origin and course of coronary artery were detected in 47 (0.49 %) of 9572 patients. The mean age of these pts was 63 ± 8. 4    the left sinus of Valsalva were seen in 8 pts (17%).The Left Coronary Artery originates from the right sinus of Valsalva in 5 pts (10.6%), in this subgroup, a patient presented by myocardial infarction resulting cardiac arrest was notified, the surgical re-implantation of LCA was performed .The RCA arising from the LAD in 2pts (4,2%). Absent RCA in 2 case (4.2%) and single coronary artery from LSV in one case (2.1%). The Left Coronary Artery arising from the Pulmonary Artery (ALCAPA) in 2 cases (4.2%) and The RCA originating from the PA (RCAPA) in one case (2.1%) ( Table 1) This patient is of 52 ages, presented by atypical chest pain, the single coronary artery originating from LSV. The other case report of Panduranga, et al. [5] revealed the single coronary artery arising from RSV with exertional angina (Figure 1) [6,7].
We have in our study one young patient of 24 years old that had been transferred to the hospital by cardiac arrest, related to this anomaly. Operative re-implanted had been indicated to save the patient (Figures 2-10).

Discussion and Conclusion
In our study, coronary anomalies of origin and course were detected in 47 of 9572 patients (0,49%) that is consistent with the incidence of 0.27% to 1.66% reported in other series. The most frequent anomaly of origin and course was the Cx Artery arising from RCA/RSV (31.9% of anomaly prevalence and 0.16% among all patients), this incidence is lower than previous published studies.
The anomalies of origin and course of RCA were found in 17% and 4.2% respectively from LSV and LAD. This incidence is lower in comparison with previous study.
Sudden deaths, myocardial infarction, arrhythmias related to the coronary anomalies were reported previously. But these anomalies often asymptomatic, so early detection of coronary anomalies of origin and course is highly important.
The former studies mainly based on the result of coronary angiography that is invasive modality. This study demonstrates MDCT is the noninvasive modality that provides important information related to coronary anatomy. Currently MDCT and MRI become fundamental to detection and diagnosis of coronary anomalies.